There are three general means to treat Corneal Endothelial Degeneration:
PALLIATIVE MEDICAL THERAPY
Palliative therapy attempts to slow the progression of the disease, while managing the painful secondary complications of the condition. Topical medical therapy, such as hypertonic saline ointment and non-steroidal anti-inflammatory drugs (NSAIDS), help to minimize the accumulation of fluid in the top layer of the cornea and prevent fluid blisters or “bullae” from forming. In more advanced states of CED, medical therapy is unable to control the formation of the fluid blisters, and these can rupture to produce painful, slow-healing corneal erosions and ulcers. When non-healing ulcers develop, we commonly need to assist in the healing process with procedures such as diamond burr debridement and/or grid keratotomy, corneal cross-linking (CXL), or thermokeratoplasty.
PALLIATIVE SURGICAL THERAPY
Surgical therapy is the only real means to make a difference in the underlying pathophysiology of this condition. A wide array of surgical procedures may slow or reverse the changes seen with CED. These include Gundersen flap placement (keratectomy and conjunctival graft), corneal cross-linking (CXL), superficial keratectomy with CXL, penetrating keratoplasty (PK) and Descemet’s stripping endothelial keratoplasty (DSEK). A Gundersen flap can be helpful early on (prior to the development of diffuse corneal edema) to help halt the clinical progression of disease and to eliminate the potential for recurrent corneal erosions in the region of graft placement. It can, however, result in a relatively opaque graft on the surface of eye. The cross-linking procedures have been shown to benefit by eliminating chronic non-healing erosions; however these procedures have not shown lasting results in regard to clearing of the cornea.
CORNEAL TRANSPLANT PROCEDURES
From a biologic standpoint, the only way to “cure” CED is to replace the diseased inner layer of the cornea with a new healthy layer of cells. This can only be accomplished with a corneal transplant procedure. Historically, this has been done with a full-thickness corneal transplant, or “penetrating keratoplasty.” This procedure has worked very well for some patients, but also carries a high risk of secondary complications such as graft rejection (failure of improvement in transparency), wound dehiscence (break down of the incision) and glaucoma (high pressure in the eye).
A newer procedure called Descemet’s stripping endothelial keratoplasty (DSEK) has significantly improved outcomes in canine corneal transplantation. The goal of DSEK is to take a completely opaque CED compromised cornea, such as the one shown above, and to selectively transplant only the diseased endothelium, ultimately resulting in fewer post-operative complications, lower rates of rejection, and increased visual outcomes.
Animal Vision Center of Virginia is one of only a small handful of practices in the world that is currently performing DSEK to restore sight in dogs.